Oxytocin and vasopressin are neurohypophyseal hormones with sequence similarity and play a central role in bodily homeostatic regulation. Pain is currently understood to be an important phenotype that those two neurohormones strongly downregulate. Nociceptors, the first component of the ascending neural circuit for pain signals, have constantly been shown to be modulated by those peptides. The nociceptor modulation appears to be critical in pain attenuation, which has led to a gradual increase in scientific interest about their physiological processes and also drawn attention to their translational potentials. This review focused on what are recently understood and stay under investigation in the functional modulation of nociceptors by oxytocin and vasopressin. Effort to produce a nociceptor-specific view could help to construct a more systematic picture of the peripheral pain modulation by oxytocin and vasopressin.

催产素和加压素是具有序列相似性的神经垂体激素，在身体稳态调节中起核心作用。疼痛目前被认为是这两种神经激素强烈下调的重要表型。伤害感受器是疼痛信号上行神经回路的第一个组成部分，不断被证明受到这些肽的调节。伤害感受器调节似乎对减轻疼痛至关重要，这导致对其生理过程的科学兴趣逐渐增加，并引起人们对其转化潜力的关注。这篇综述着重于最近在催产素和加压素对伤害感受器的功能调节方面的理解和研究。