Background/aims To investigate the relationship between the foveal avascular zone (FAZ) parameters assessed by optical coherence tomography angiography (OCTA) and central visual field parameters in glaucoma and healthy subjects. Methods One hundred and eighty-eight subjects (248 eyes), including 24 healthy (38 eyes), 37 glaucoma suspect (42 eyes, and 127 primary open angle glaucoma (POAG) patients (168 eyes), underwent imaging using OCTA and standard automated perimetry using the 24-2 and 10-2 Swedish Interactive Thresholding Algorithm. OCTA-based and OCT-based FAZ parameters (superficial FAZ area, FAZ circumference), foveal vessel density (FD300) and foveal thickness were measured. The correlation between FAZ parameters and visual field parameters was assessed using linear mixed model. Results Axial length adjusted-FAZ area was not different among the three groups (mean (95% CI)): in healthy 0.31 (0.27 to 0.36) mm2, glaucoma suspect 0.29 (0.26 to 0.31) mm2 and POAG eyes 0.28 (0.27 to 0.30) mm2 (p=0.578). FD300 was lower in glaucoma suspect 49.1% (47.9% to 50.4%) and POAG eyes 48.7% (48.1% to 49.4%) than healthy eyes 50.5% (49.3% to 51.7%) though the difference was not statistically significant (p=0.071). Lower FD300 was associated with worse 24-2 and 10-2 visual field mean deviation and foveal threshold in multivariable linear mixed models (all p<0.05). In addition, a smaller FAZ area was associated with lower intraocular pressure (IOP) (p=0.026). Conclusions The FD300, but not the FAZ area was correlated with 10° central visual field mean deviation and foveal threshold in healthy, glaucoma suspect and POAG eyes. In contrast, a smaller FAZ area was associated with lower IOP. Data are available on reasonable request. The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.

中文翻译：

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青光眼的中央黄斑 OCTA 参数

背景/目的 研究通过光学相干断层扫描血管造影术 (OCTA) 评估的中心凹无血管区 (FAZ) 参数与青光眼和健康受试者的中央视野参数之间的关系。方法 188 名受试者（248 只眼），包括 24 名健康人（38 只眼）、37 名疑似青光眼患者（42 只眼）和 127 名原发性开角型青光眼 (POAG) 患者（168 只眼），使用 OCTA 和标准自动化进行成像使用 24-2 和 10-2 瑞典交互式阈值算法进行视野测量。测量基于 OCTA 和基于 OCT 的 FAZ 参数（表面 FAZ 面积、FAZ 周长）、中心凹血管密度 (FD300) 和中心凹厚度。FAZ 参数之间的相关性使用线性混合模型评估视野参数。结果 眼轴长度调整后的 FAZ 面积在三组之间没有差异（平均值（95% CI））：健康眼为 0.31（0.27 至 0.36）mm2，疑似青光眼眼为 0.29（0.26 至 0.31）mm2，POAG 眼为 0.28（0.27 至 0.30）mm2 ) mm2 (p=0.578)。疑似青光眼 49.1%（47.9% 至 50.4%）和 POAG 眼 48.7%（48.1% 至 49.4%）的 FD300 低于健康眼 50.5%（49.3% 至 51.7%），尽管差异无统计学意义（p=0.071） ). 在多变量线性混合模型中，较低的 FD300 与较差的 24-2 和 10-2 视野平均偏差和中心凹阈值相关（所有 p < 0.05）。此外，较小的 FAZ 区域与较低的眼压 (IOP) 相关 (p=0.026)。结论 在健康眼、疑似青光眼眼和 POAG 眼中，FD300 而不是 FAZ 面积与 10° 中央视野平均偏差和中心凹阈值相关。相比之下，较小的 FAZ 区域与较低的 IOP 相关。可应合理要求提供数据。当前研究期间生成和/或分析的数据集可根据合理要求从相应的作者处获得。