Inula cappa (Buch.-Ham. ex D. Don) DC has been used in traditional Chinese medicine to treat malaria, dysentery, and hepatitis. Previous studies have shown that chlorogenic acid is the effective ingredient of plants in this family. And the research of the chlorogenic acid in Inula cappa will help to further improve the effective resource utilization rate of this plant. Therefore, it is necessary to establish an accurate method to characterize the chlorogenic acid components in Inula cappa. In this study, a simple, fast, and sensitive UHPLC-Q-Exactive Orbitrap mass spectrometry method was established, which can simultaneously analyze known and unknown ingredients in a short time (within 30 minutes) in Inula cappa. According to the diagnosis fragmentation ions, retention time, and bibliography, 68 chlorogenic acid derivatives were identified in Inula cappa. The results of this experiment lay the foundation for the active substances and quality control of Inula cappa and provide a theoretical basis for whether Inula cappa can be an alternative to the endangered wild medicinal materials of the same family.

中文翻译：

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使用 UHPLC-Q-Exactive Orbitrap 质谱法基于诊断碎片离子快速鉴定 Inula cappa 中的绿原酸衍生物

Inula cappa (Buch.-Ham. ex D. Don) DC 已在中药中用于治疗疟疾、痢疾和肝炎。以往的研究表明，绿原酸是该科植物的有效成分。而对木薯中绿原酸的研究将有助于进一步提高该植物的有效资源利用率。因此，有必要建立一种准确的方法来表征木薯中的绿原酸成分。本研究建立了一种简单、快速、灵敏的 UHPLC-Q-Exactive Orbitrap 质谱方法，可以在短时间内（30 分钟内）同时分析Inula cappa 中的已知和未知成分。根据诊断碎裂离子、保留时间和参考文献，在Inula cappa中鉴定出68种绿原酸衍生物。本实验结果为木薯的活性物质和质量控制奠定了基础，为木薯能否替代同科濒危野生药材提供了理论依据。