Abstract

A series of quercetin derivatives were synthesized via Williamson etherification, Steglich esterification or Koenigs–Knorr glycosylation reaction at 3 and 7 position hydroxyl groups selectively. The structures of the synthesized compounds were characterized and identified by IR, ¹H NMR, ¹³C NMR and HR-MS. The antioxidant capacity of synthesized compounds was determined by total antioxidant capacity assay kit with ABTS method (T-AOC Assay Kit). The results revealed that the compounds Qr-5a, Qr-5b, Qr-5c, Qr-5d and Qr-12 manifested significant antioxidant activities comparing to that of the positive control rutin (TEAC = 3.28), among which the antioxidant capacity of Qr-12 was the strongest, and the TEAC value was 5.19.

摘要

通过威廉姆森醚化、Steglich酯化或Koenigs-Knorr糖基化反应选择性地在3位和7位羟基上合成了一系列槲皮素衍生物。合成化合物的结构经IR、¹ H NMR、¹³ C NMR和HR-MS表征和鉴定。合成化合物的抗氧化能力采用ABTS法总抗氧化能力测定试剂盒(T-AOC Assay Kit)测定。结果表明，化合物Qr-5a、Qr-5b、Qr-5c、Qr-5d和Qr-12与阳性对照芦丁相比（TEAC=3.28）表现出显着的抗氧化活性，其中Qr-12的抗氧化能力最强，TEAC值为5.19。