Innate immune responses play key roles in the initiation and perpetuation of a variety of systemic autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).(1) While effective biologics and small molecules targeting innate and adaptive immune responses in these diseases are currently available, there are still significant gaps in the development of therapies that can hamper innate immune dysregulation in certain subgroups of patients where this pathway may play crucial pathogenic roles.

中文翻译：

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在系统性自身免疫中靶向 myddosome——准备好迎接黄金时段了吗？

先天性免疫反应在各种系统性自身免疫性疾病的发生和持续中起着关键作用，包括类风湿性关节炎 (RA) 和系统性红斑狼疮 (SLE)。(1) 虽然针对这些疾病的先天性和适应性免疫反应的有效生物制剂和小分子药物尽管目前有多种疾病可用，但在可能阻碍某些患者亚群的先天免疫失调的疗法的开发方面仍然存在重大差距，在这些亚群中，该途径可能发挥关键的致病作用。