The vascular endothelium is a monolayer of flat epithelial cells located between the circulating blood and the underlying connective tissue. It conveys key functions that when impaired, lead to endothelial dysfunction. This condition is responsible for the pathogenesis of vascular diseases. The cardioprotective effect of sex hormones is widely known; hence, a murine orchidectomized model has been employed to study the effects caused by their deficiency. In the search for approaches to maintain vascular health, the effect of dietary fatty acids as CLA on cardiovascular diseases has been studied. Some proven beneficial properties of CLA are antioxidant, antiatherogenic and anti-inflammatory. Our objective was to evaluate the effect of a diet supplemented with 1.8 % (w/w) of CLA, administered during eight weeks, on the amount of cholesterol oxidation products (COPs) produced by orchidectomy and on factors related to vascular dysfunction in the aorta and the mesenteric arteries. The diet with CLA prevented the increase in prostanoids formation and maintained the normal physiological conditions of NO and antioxidant activity. In addition, it prevented the increase in cholesterol and COPs at the vascular wall. CLA-supplemented diet prevented the orchidectomy-induced alterations on prostanoids, NO and COPs and also improved the antioxidant activity. These findings could contribute to understand the mechanisms of actions of CLA involved in the prevention of cardiovascular diseases.

血管内皮是位于循环血液和下面的结缔组织之间的扁平上皮细胞的单层。它传达了当受损时会导致内皮功能障碍的关键功能。这种情况是导致血管疾病发病机制的原因。性激素的心脏保护作用是众所周知的。因此，已采用小鼠兰花切除模型来研究其缺乏引起的影响。在寻找维持血管健康的方法时，已经研究了作为 CLA 的膳食脂肪酸对心血管疾病的影响。CLA 的一些经证实的有益特性是抗氧化、抗动脉粥样硬化和抗炎。我们的目标是评估补充 1.8 % (w/w) CLA 的饮食在八周内的效果，睾丸切除术产生的胆固醇氧化产物 (COP) 的数量以及与主动脉和肠系膜动脉血管功能障碍相关的因素。含有 CLA 的饮食阻止了前列腺素形成的增加，并保持了 NO 和抗氧化活性的正常生理条件。此外，它还阻止了血管壁胆固醇和 COP 的增加。补充 CLA 的饮食可防止睾丸切除术引起的前列腺素、NO 和 COP 的变化，并提高抗氧化活性。这些发现有助于了解 CLA 在预防心血管疾病中的作用机制。含有 CLA 的饮食阻止了前列腺素形成的增加，并保持了 NO 和抗氧化活性的正常生理条件。此外，它还阻止了血管壁胆固醇和 COP 的增加。补充 CLA 的饮食可防止睾丸切除术引起的前列腺素、NO 和 COP 的变化，并提高抗氧化活性。这些发现有助于了解 CLA 在预防心血管疾病中的作用机制。含有 CLA 的饮食阻止了前列腺素形成的增加，并保持了 NO 和抗氧化活性的正常生理条件。此外，它还阻止了血管壁胆固醇和 COP 的增加。补充 CLA 的饮食可防止睾丸切除术引起的前列腺素、NO 和 COP 的变化，并提高抗氧化活性。这些发现有助于了解 CLA 在预防心血管疾病中的作用机制。