Bioadhesive polymers offer versatility to medical and pharmaceutical inventions. The incorporation of such materials to conventional dosage forms or medical devices may confer or improve the adhesivity of the bioadhesive systems, subsequently prolonging their residence time at the site of absorption or action and providing sustained release of actives with improved bioavailability and therapeutic outcomes. For decades, much focus has been put on scientific works to replace synthetic polymers with biopolymers with desirable functional properties. Gelatine has been considered one of the most promising biopolymers. Despite its biodegradability, biocompatibility and unique biological properties, gelatine exhibits poor mechanical and adhesive properties, limiting its end-use applications. The chemical modification and blending of gelatine with other biomaterials are strategies proposed to improve its bioadhesivity. Here we discuss the classical approaches involving a variety of polymer blends and composite systems containing gelatine, and gelatine modifications via thiolation, methacrylation, catechol conjugation, amination and other newly devised strategies. We highlight several of the latest studies on these strategies and their relevant findings.

生物粘附聚合物为医学和制药发明提供了多功能性。将此类材料掺入常规剂型或医疗器械可赋予或改善生物粘附系统的粘附性，随后延长其在吸收或作用部位的停留时间，并提供具有改进的生物利用度和治疗效果的活性物质的持续释放。几十年来，科学工作一直备受关注，以用具有理想功能特性的生物聚合物代替合成聚合物。明胶被认为是最有前途的生物聚合物之一。尽管具有可生物降解性、生物相容性和独特的生物特性，但明胶的机械和粘合性能较差，限制了其最终用途。明胶与其他生物材料的化学改性和混合是提高其生物粘附性的策略。在这里，我们讨论了涉及各种聚合物共混物和含有明胶的复合系统的经典方法，以及通过硫醇化、甲基丙烯酸化、儿茶酚结合、胺化和其他新设计的策略对明胶进行改性。我们重点介绍了关于这些策略及其相关发现的几项最新研究。