The aim of the study was to prepare catechin-loaded transfersomes to enhance drug permeability through topical administration for the skin protection against ultraviolet radiation induced photo-damage. The results showed that the catechin-loaded transfersomes were monodispersed with polydispersity index (PDI) < 0.2, <200 nm in particle size and with high encapsulation efficiency (E.E.%) greater than 85%. The in vitro skin permeation test indicated that the catechin-loaded transfersomes enhanced the skin permeability by 85% compared to the catechin aqueous solution. Similarly, the in-vivo skin whitening study demonstrated that F5 transfersome formulation was effective in tyrosinase inhibition and had good biocompatibility to the guinea pig skin. Finally, the stability study showed that both physicochemical properties and E.E.% of the F5 transferosome formulation were fairly stable after 3 months storage. Therefore, topical administration of catechin-loaded transfersomes could be considered as a potential strategy for the treatment of UV-induced oxidative damage to the skin.

该研究的目的是制备装载儿茶素的传递体，通过局部给药来增强药物渗透性，以保护皮肤免受紫外线辐射引起的光损伤。结果表明，装载儿茶素的传递体是单分散的，多分散指数 (PDI) < 0.2，粒径 <200 nm，包封率 (EE%) 大于 85%。的体外皮肤透过试验表明，儿茶素的加载传递体S按85％相比，儿茶素水溶液增强皮肤渗透性。同样，体内皮肤美白研究表明，F5传递体配方能有效抑制酪氨酸酶，对豚鼠皮肤具有良好的生物相容性。最后，稳定性研究表明，F5 转移体制剂的物理化学性质和 EE% 在储存 3 个月后都相当稳定。因此，局部施用装载儿茶素的传递体可被视为治疗紫外线引起的皮肤氧化损伤的潜在策略。