Interleukin-27 (IL-27), a member of the IL-6/IL-12 family, has diverse regulatory functions in various immune responses, and is recognised as a potent agonist and antagonist of CD4+T cells in different contexts. However, this dual role and underlying mechanisms have not been completely defined. In the present review, we summarise the dual role of IL-27 in CD4+T cells. In particular, we aimed to decipher its mechanism to better understand the context-dependent function of IL-27 in CD4+T cells. Furthermore, we propose a possible mechanism for the dual role of IL-27. This may be helpful for the development of appropriate IL-27 treatments in various clinical settings.

白细胞介素 27 (IL-27) 是 IL-6/IL-12 家族的一员，在各种免疫反应中具有多种调节功能，被认为是不同环境下 CD4+T 细胞的有效激动剂和拮抗剂。然而，这种双重作用和潜在机制尚未完全定义。在本综述中，我们总结了 IL-27 在 CD4+T 细胞中的双重作用。特别是，我们旨在破译其机制，以更好地了解 IL-27 在 CD4+T 细胞中的上下文相关功能。此外，我们提出了 IL-27 双重作用的可能机制。这可能有助于在各种临床环境中开发适当的 IL-27 治疗方法。