Base-promoted Synthesis of Trifluoromethylated (1,3-dioxolan-4-ylidene)methylphosphonates from Trifluoromethylketones and Ethynylphosphonates,Asian Journal of Organic Chemistry

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Base-promoted Synthesis of Trifluoromethylated (1,3-dioxolan-4-ylidene)methylphosphonates from Trifluoromethylketones and Ethynylphosphonates
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-08-22 , DOI: 10.1002/ajoc.202100428
Alexander Mitrofanov ₁ , Sergey E. Nefedov ₂ , Irina P. Beletskaya ₃

Affiliation

Convenient approach to a series of CF₃-functionalized (1,3-dioxolan-4-ylidene)methylphosphonates using trifluoromethylketones and different alkynylphosphonate was developed. In the case of diethyl ethynylphosphonates reaction smoothly proceed at room temperature in the presence of KO-tBu giving 2,5-bistrifluoromethylated 1,3-dioxolanes derivatives in high yields. Diethyl (3-hydroxyprop-1-yn-1-yl)phosphonates resulted 2-CF₃-fuctionalized derivatives in good yields.

中文翻译：

从三氟甲基酮和乙炔基膦酸酯中碱促进合成三氟甲基化 (1,3-二氧戊环-4-亚基) 甲基膦酸酯

开发了使用三氟甲基酮和不同的炔基膦酸酯制备一系列 CF ₃ -官能化（1,3-二氧戊环-4-亚基）甲基膦酸酯的便捷方法。在乙炔基膦酸二乙酯的情况下，反应在室温下在 KO - t Bu存在下顺利进行，以高产率得到 2,5-双三氟甲基化 1,3-二氧戊环衍生物。(3-羟基丙基-1-yn-1-基)膦酸二乙酯以良好的产率产生2-CF _{3 -}功能化衍生物。

更新日期：2021-10-19

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