Understanding the neural underpinnings of major depressive disorder (MDD) and its treatment could improve treatment outcomes. So far, findings are variable and large sample replications scarce. We aimed to replicate and extend altered functional connectivity associated with MDD and pharmacotherapy outcomes in a large, multisite sample. Resting-state fMRI data were collected from 129 patients and 99 controls through the Canadian Biomarker Integration Network in Depression. Symptoms were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS). Connectivity was measured as correlations between four seeds (anterior and posterior cingulate cortex, insula and dorsolateral prefrontal cortex) and all other brain voxels. Partial least squares was used to compare connectivity prior to treatment between patients and controls, and between patients reaching remission (MADRS ≤ 10) early (within 8 weeks), late (within 16 weeks), or not at all. We replicated previous findings of altered connectivity in patients. In addition, baseline connectivity of the anterior/posterior cingulate and insula seeds differentiated patients with different treatment outcomes. The stability of these differences was established in the largest single-site subsample. Our replication and extension of altered connectivity highlighted previously reported and new differences between patients and controls, and revealed features that might predict remission prior to pharmacotherapy. Trial registration: ClinicalTrials.gov: NCT01655706.

中文翻译：

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16 周药物治疗后与抑郁和缓解状态相关的静息状态网络的基线功能连接：CAN-BIND 报告

了解重度抑郁症 (MDD) 的神经基础及其治疗可以改善治疗结果。到目前为止，发现是多变的，大样本复制很少。我们的目标是在大型多站点样本中复制和扩展与 MDD 和药物治疗结果相关的改变的功能连接。通过加拿大抑郁症生物标志物整合网络从 129 名患者和 99 名对照中收集了静息状态 fMRI 数据。使用蒙哥马利-埃斯伯格抑郁量表 (MADRS) 评估症状。连接性被测量为四个种子（前和后扣带皮层、岛叶和背外侧前额叶皮层）与所有其他脑体素之间的相关性。偏最小二乘法用于比较患者和对照治疗前的连通性，以及在早期（8 周内）、晚期（16 周内）或根本没有达到缓解（MADRS ≤ 10）的患者之间。我们复制了先前关于患者连接性改变的发现。此外，前/后扣带回和岛叶种子的基线连通性区分了具有不同治疗结果的患者。这些差异的稳定性是在最大的单点子样本中建立的。我们对改变连接性的复制和扩展突出了先前报道的患者和对照组之间的新差异，并揭示了可能预测药物治疗前缓解的特征。试验注册：ClinicalTrials.gov：NCT01655706。此外，前/后扣带回和岛叶种子的基线连通性区分了具有不同治疗结果的患者。这些差异的稳定性是在最大的单点子样本中建立的。我们对改变连接性的复制和扩展突出了先前报道的患者和对照组之间的新差异，并揭示了可能预测药物治疗前缓解的特征。试验注册：ClinicalTrials.gov：NCT01655706。此外，前/后扣带回和岛叶种子的基线连通性区分了具有不同治疗结果的患者。这些差异的稳定性是在最大的单点子样本中建立的。我们对改变连接性的复制和扩展突出了先前报道的患者和对照组之间的新差异，并揭示了可能预测药物治疗前缓解的特征。试验注册：ClinicalTrials.gov：NCT01655706。我们对改变连接性的复制和扩展突出了先前报道的患者和对照组之间的新差异，并揭示了可能预测药物治疗前缓解的特征。试验注册：ClinicalTrials.gov：NCT01655706。我们对改变连接性的复制和扩展突出了先前报道的患者和对照组之间的新差异，并揭示了可能预测药物治疗前缓解的特征。试验注册：ClinicalTrials.gov：NCT01655706。