Background

Inadequate meibomian glands (MGs) secretion can lead to dry eye signs and symptoms. Tear film lipid layer (TFLL) secreted by MGs protects and prevents rapid evaporation of tear film. The purpose was to assess TFLL alteration and function in patients with evaporative dry eye (EDE) using tear interferometry after optimal pulse light technology (OPT) intense pulsed light (IPL).

Methods

This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month.

Results

At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P < 0.05) in the IPL group, while the sham group had no significant improvements. Except for Meibo-score and FS, all parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards.

Conclusion

IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears use.

中文翻译：

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干眼病强脉冲光后泪膜干涉法评估：一项随机、单盲、假对照研究

背景

睑板腺 (MG) 分泌不足会导致干眼症的体征和症状。MGs 分泌的泪膜脂质层 (TFLL) 可保护和防止泪膜快速蒸发。目的是在最佳脉冲光技术 (OPT) 强脉冲光 (IPL) 后使用泪液干涉仪评估蒸发过强型干眼 (EDE) 患者的 TFLL 改变和功能。

方法

这项前瞻性随机检查者蒙面假对照研究包括 86 名 DED 参与者（142 只眼）。在第 0、21 和 42 天进行 IPL 或假手术。眼表疾病指数 (OSDI)、非侵入性破裂时间 (NITBUT)、干涉条纹图案确定 TFLL 质量、荧光素染色 (FS) 和睑脂腺 (MG ) 在第 0 天、第 21 天、第 42 天和第 3 个月进行评估。

结果

3个月时，IPL组TFLL、NITBUT、MG drop-out、MG质量、MG表达性、FS和OSDI显着改善（P < 0.05），而假手术组无明显改善。除了 Meibo-score 和 FS，所有参数都与 IPL 治疗后 TFLL 的改善显着相关。此外，从 D-42 开始，IPL 组的人工泪液使用量显着减少。

结论

IPL 治疗证明了提高 TFLL 质量和临床上减少 DED 的体征和症状的能力，从而降低了人工泪液的使用频率。