Frailty is the physiological stress that individuals suffer during their life. In past populations, frailty is conventionally assessed through the occurrence of different biomarkers of biological stress. Some efforts have been made to propose indexes that combine all biomarkers. However, these indices have some critical limitations: they cannot be used on incomplete skeletons, do not consider the severity and/or healing of lesions, and assign equal importance to different biomarkers. To address these limitations, we propose a new index to assess frailty in skeletal individuals.

中文翻译：

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脆弱的生物学指数：评估人类骨骼遗骸脆弱的新指标

虚弱是个体在其一生中遭受的生理压力。在过去的人群中，通常通过不同生物压力生物标志物的出现来评估虚弱。已经做出了一些努力来提出结合所有生物标志物的索引。然而，这些指标有一些严重的局限性：它们不能用于不完整的骨骼，不考虑病变的严重程度和/或愈合情况，并且对不同的生物标志物赋予同等的重要性。为了解决这些限制，我们提出了一个新的指数来评估骨骼个体的虚弱程度。