The continuous-wave back reflection diffuse optical tomography (rCWDOT) system is one of the new medical imaging modalities. This study examines the success of reconstruction and three-dimensional (3D) image processing algorithms on data obtained from a heterogonous breast phantom by rCWDOT. Breast phantoms were prepared by putting a bit of spleen inside the tail. The spleen mimics a breast tumor since it has more blood than tail fat. rCWDOT was used to acquire data from the breast phantoms. The breast phantoms were reconstructed using the transpose-free quasi-minimal residual (TFQMR) reconstruction algorithm. Then, image processing algorithms were performed to improve the image quality. In image processing, 3D Gaussian filtering and bi-cubic interpolation were used to enhance the appearance and remove noise from the images. After the image processing, the images were evaluated numerically using the peak signal-to-noise ratio (PSNR) method. It has been shown that the used reconstruction technique and image processing algorithms for a heterogeneous breast phantom provided 3D images that resemble actual ones. This study will help researchers use the most convenient reconstruction algorithm and image processing algorithms and perform preclinical experiments in this field.

中文翻译：

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使用用于漫反射光学成像的重建和三维图像处理算法对异质乳房模型进行临床前研究的方法

连续波背反射漫反射光学断层扫描 (rCWDOT) 系统是一种新的医学成像模式。这项研究检查了重建和三维 (3D) 图像处理算法对通过 rCWDOT 从异质乳房模型获得的数据的成功。通过在尾巴内放置一点脾脏来制备乳房模型。脾脏模仿乳腺肿瘤，因为它的血液比尾部脂肪多。rCWDOT 用于从乳房模型中获取数据。使用无转置准最小残差 (TFQMR) 重建算法重建乳房模型。然后，执行图像处理算法以提高图像质量。在图像处理中，使用 3D 高斯滤波和双三次插值来增强图像的外观并去除图像中的噪声。图像处理后，使用峰值信噪比 (PSNR) 方法对图像进行数值评估。已经表明，用于异质乳房模型的重建技术和图像处理算法提供了类似于真实图像的 3D 图像。这项研究将帮助研究人员使用最方便的重建算法和图像处理算法，并在该领域进行临床前实验。