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Polyglycerol-Based Mucus-Inspired Hydrogels
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2021-08-21 , DOI: 10.1002/marc.202100303
Antara Sharma 1 , Boonya Thongrom 1 , Sumati Bhatia 1 , Benjamin von Lospichl 2 , Annalisa Addante 3, 4, 5 , Simon Y Graeber 3, 4, 5 , Daniel Lauster 6 , Marcus A Mall 3, 4, 5 , Michael Gradzielski 2 , Rainer Haag 1
Affiliation  

The mucus layer is a hydrogel network that covers mucosal surfaces of the human body. Mucus has important protective properties that are related to its unique rheological properties, which are based on mucins being the main glycoprotein constituents. Mucin macromolecules entangle with one another and form a physical network that is instrumental for many important defense functions. Mucus derived from various human or animal sources is poorly defined and thus not suitable for many application purposes. Herein, a synthetic route is fabricated to afford a library of compositionally defined mucus-inspired hydrogels (MIHs). MIHs are synthesized by thiol oxidation to render disulfide bonds between the crosslinker ethoxylated trimethylolpropane tri(3-mercaptopropionate) (THIOCURE ETTMP 1300) and the linear precursors, dithiolated linear polyglycerol (LPG(SH)2) or polyethylene glycol (PEG(SH)2) of different molecular weights. The mixing ratio of linear polymers versus crosslinker and the length of the linear polymer are varied, thus delivering a library of compositionally defined mucin-inspired constructs. Their viscoelastic properties are determined by frequency sweeps at 25 and 37 °C and compared to the corresponding behavior of native human mucus. Here, MIHs composed of a 10:1 ratio of LPG(SH)2 and ETTMP 1300 are proved to be the best comparable to human airway mucus rheology.

中文翻译:

聚甘油基粘液水凝胶

粘液层是覆盖人体粘膜表面的水凝胶网络。粘液具有重要的保护特性,这与其独特的流变特性有关,这些特性基于粘蛋白是主要的糖蛋白成分。粘蛋白大分子相互缠结并形成一个物理网络,有助于许多重要的防御功能。来自各种人类或动物来源的粘液定义不明确,因此不适用于许多应用目的。在这里,制造了一种合成路线,以提供一个成分定义的粘液启发水凝胶 (MIH) 库。MIH 通过硫醇氧化合成,使交联剂乙氧基化三羟甲基丙烷三(3-巯基丙酸酯)(THIOCURE ETTMP 1300)和线性前体之间形成二硫键,2 ) 或不同分子量的聚乙二醇 (PEG(SH) 2 )。线性聚合物与交联剂的混合比例和线性聚合物的长度是不同的,因此提供了一个由组成定义的粘蛋白启发构建体的库。它们的粘弹性特性由 25 和 37°C 下的频率扫描确定,并与天然人类粘液的相应行为进行比较。在这里,由 10:1 比例的 LPG(SH) 2和 ETTMP 1300组成的MIH 被证明是与人类气道粘液流变学相媲美的最佳选择。
更新日期:2021-10-22
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