Recent Progress in Enolonium Chemistry under Metal-Free Conditions,The Chemical Record

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Recent Progress in Enolonium Chemistry under Metal-Free Conditions
The Chemical Record ( IF 7.0 ) Pub Date : 2021-08-21 , DOI: 10.1002/tcr.202100172
Ravi Kumar ₁ , Quynh H Nguyen ₁ , Tae-Woong Um ₁ , Seunghoon Shin ₁

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Umpolung approach through inversion of the polarity of conventional enolates, has opened up an unprecedented opportunity in the cross-coupling via alkylation. The enolonium equivalents can be accessed either by hypervalent iodine reagents, activation/oxidation of amides, or the oxidation of alkynes. Under umpolung conditions, highly basic conditions required for classical enolate chemistry can be avoided, and they can couple with unmodified nucleophiles such as heteroatom donors and electron-rich arenes.

中文翻译：

无金属条件下铒化学的最新进展

通过反转传统烯醇化物的极性的 Umpolung 方法为通过烷基化的交叉偶联开辟了前所未有的机会。可以通过高价碘试剂、酰胺的活化/氧化或炔烃的氧化来获得enolonium等价物。在 umpolung 条件下，可以避免经典烯醇化物化学所需的高碱性条件，并且它们可以与未修饰的亲核试剂（如杂原子供体和富电子芳烃）偶联。

更新日期：2021-08-21

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