Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model,The Prostate

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Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model
The Prostate ( IF 2.6 ) Pub Date : 2021-08-21 , DOI: 10.1002/pros.24214
Jing Chen _{1,

2,

3} , Li-Gang Zhang _{1,

2,

3} , He-Xi Du _{1,

2,

3} , Chang-Sheng Zhan _{1,

2,

3} , Yi Liu _{1,

2,

3} , Meng Zhang _{1,

2,

3} , Xian-Guo Chen _{1,

2,

3} , Long-Ping Wen _{1,

3,

4} , Li Zhang _{1,

2,

3,

5} , Chao-Zhao Liang _{1,

2,

3}

Affiliation

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common male genitourinary system disease. As a neuroendocrine hormone, melatonin possesses a variety of biological functions, among which its anti-inflammatory effects have recently drawn substantial attention. The purpose of the current research was to study the effect of melatonin on CP/CPPS and the underlying mechanisms using a mouse model of experimental autoimmune prostatitis (EAP).

中文翻译：

在 EAP 小鼠模型中，褪黑激素通过 Sirt1 依赖性抑制 NLRP3 炎性体减轻前列腺炎症和盆腔疼痛

慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）是一种常见的男性泌尿生殖系统疾病。褪黑激素作为一种神经内分泌激素，具有多种生物学功能，其中抗炎作用近年来备受关注。本研究的目的是使用实验性自身免疫性前列腺炎 (EAP) 小鼠模型研究褪黑激素对 CP/CPPS 的影响及其潜在机制。

更新日期：2021-09-23

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