Tetrahedron ( IF 2.1 ) Pub Date : 2021-08-21 , DOI: 10.1016/j.tet.2021.132409 Ye Meng 1 , Yan-Mei Jin 1 , Pei-Hua Ma 1
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In this study, cyclohexanol was used as the raw material to replace cyclohexanone during the synthesis of symmetric dicyclohexanocucurbit[6]uril (CyH2Q[6]), which successfully avoided the use of selenium dioxide and greatly improved the yield of cyclohexyl-substituted glycoluril as the intermediate product (96%). In addition, using CyH2Q[6] as the host molecule and glycine (Gly) as the guest, the interaction mode between the two in both an aqueous and solid phase was studied using 1H NMR spectroscopy and X-ray crystallography. Analysis of the 1H NMR spectra and crystal structure showed that CyH2Q[6] and Gly form a 1:2 host–guest inclusion compound.
中文翻译：
对称双环己葫芦[6]脲的合成及其与甘氨酸的相互作用
本研究以环己醇为原料在对称双环己基葫芦[6]脲(CyH 2 Q[6])的合成过程中取代环己酮，成功避免了二氧化硒的使用，大大提高了环己基取代的收率。甘脲作为中间产物（96%）。此外，以CyH 2 Q[6]为主体分子，甘氨酸(Gly)为客体，利用1 H NMR光谱和X射线晶体学研究了两者在水相和固相中的相互作用模式。所述的分析1层1 H NMR光谱和晶体结构表明，CYH 2 Q [6]和甘氨酸形成1：2主客体包合物。
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