It has been implied that there is a possible relationship between cyclin-dependent protein kinase inhibitors antisense RNA 1 (CDKN2B-AS1) gene rs4977574 A/G polymorphism and coronary heart disease (CHD) susceptibility. However, as the research results are discrepant, no distinct consensus on this issue has been reached so far. In order to further elaborate the latent association of the CDKN2B-AS1 gene rs4977574 A/G polymorphism and CHD, this present meta-analysis was conducted. There were 40,979 subjects of 17 individual studies in the present meta-analysis. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated to determine the association strength. Considering the significant heterogeneity among the individual studies, the random-effect models were used. In the current meta-analysis, a significant association between CDKN2B-AS1 gene rs4977574 A/G polymorphism and CHD was found under allelic (OR: 1.18, 95% CI: 1.08–1.29, p = 4.83×10⁻⁴), recessive (OR: 1.36, 95% CI: 1.11–1.67, p = 0.003), dominant (OR: 0.71, 95% CI: 0.58–0.86, p = 6.26×10⁻⁴), heterozygous (OR:1.210, 95% CI: 1.076–1.360, p = 0.001), homozygous (OR: 1.394, 95% CI: 1.163–1.671, p = 3.31×10⁻⁴) and additive (OR: 1.180, 95% CI: 1.075–1.295, p = 4.83×10⁻⁴) genetic models. A more significant association between them was found in the Asian population than that in the whole population under these genetic models (p < 0.05). However, no significant association between them was found in the Caucasian population (p > 0.05). CDKN2B-AS1 gene rs4977574 A/G polymorphism was associated with CHD susceptibility, especially in the Asian population. G allele of CDKN2B-AS1 gene rs4977574 A/G polymorphism is the risk allele for CHD.

中文翻译：

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CDKN2B-AS1 基因 rs4977574 A/G 多态性与冠心病：40,979 名受试者的荟萃分析

已经暗示细胞周期蛋白依赖性蛋白激酶抑制剂反义 RNA 1 ( CDKN2B-AS1 ) 基因 rs4977574 A/G 多态性与冠心病 (CHD) 易感性之间可能存在关系。但由于研究结果参差不齐，目前尚未就该问题达成明确共识。为了进一步阐述CDKN2B-AS1的潜在关联基因 rs4977574 A/G 多态性和 CHD，进行了本荟萃分析。本荟萃分析共有 17 项独立研究的 40,979 名受试者。估计汇总优势比 (OR) 及其相应的 95% 置信区间 (CI) 以确定关联强度。考虑到各个研究之间的显着异质性，使用了随机效应模型。在目前的荟萃分析中，CDKN2B-AS1基因 rs4977574 A/G 多态性与 CHD 之间存在显着关联，在等位基因（OR：1.18，95% CI：1.08-1.29，p  = 4.83×10 ^-4）、隐性（ OR: 1.36, 95% CI: 1.11–1.67, p  = 0.003)，显性 (OR: 0.71, 95% CI: 0.58–0.86, p  = 6.26×10 ^-4)、杂合子 (OR:1.210, 95% CI: 1.076–1.360, p  = 0.001)、纯合子 (OR: 1.394, 95% CI: 1.163–1.671, p  = 3.31×10 ^-4 ) 和加性 (OR: 1.180, 95% CI：1.075–1.295，p  = 4.83×10 ^-4 ) 遗传模型。在这些遗传模型下，在亚洲人群中发现它们之间的关联比在整个人群中更显着（p  < 0.05）。然而，在高加索人群中没有发现它们之间的显着关联（p  > 0.05）。CDKN2B-AS1基因rs4977574 A/G 多态性与冠心病易感性相关，尤其是在亚洲人群中。CDKN2B - AS1的G等位基因基因rs4977574 A/G多态性是冠心病的风险等位基因。