ABSTRACT

PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.

中文翻译：

---

Rhodiasolv PolarClean – 固相肽合成中更环保的替代品

摘要

PolarClean 是一种通过对 Nylon-66 制造副产品进行增值制备的绿色溶剂，显示出溶解所有 Fmoc-氨基酸以及关键偶联试剂和添加剂的出色能力。它还可以溶胀聚苯乙烯和 ChemMatrix，这两种树脂是固相肽合成中应用最广泛的树脂。已经进行了模型肽的合成，使目标肽成为主要成分。PolarClean 的性能证明了其在绿色固相肽合成工具箱中的实用性。