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Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis
Green Chemistry Letters and Reviews ( IF 5.8 ) Pub Date : 2021-08-22 , DOI: 10.1080/17518253.2021.1965663
Ashish Kumar 1, 2 , Anamika Sharma 1, 2 , Beatriz G. de la Torre 2 , Fernando Albericio 1, 3, 4
Affiliation  

ABSTRACT

PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.



中文翻译:

Rhodiasolv PolarClean – 固相肽合成中更环保的替代品

摘要

PolarClean 是一种通过对 Nylon-66 制造副产品进行增值制备的绿色溶剂,显示出溶解所有 Fmoc-氨基酸以及关键偶联试剂和添加剂的出色能力。它还可以溶胀聚苯乙烯和 ChemMatrix,这两种树脂是固相肽合成中应用最广泛的树脂。已经进行了模型肽的合成,使目标肽成为主要成分。PolarClean 的性能证明了其在绿色固相肽合成工具箱中的实用性。

更新日期:2021-08-23
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