Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2021-08-21 , DOI: 10.1007/s11418-021-01559-1 Qing-Wei Fang 1 , Wen-Wei Fu 1 , Jin-Ling Yang 1 , Yue Lu 1 , Jiang-Cheng Chen 1 , Pei-Ying Wu 2 , Xue Zhang 2 , Hong-Xi Xu 1, 3
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One new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins N-P (2–4), along with nine known compounds were isolated from the dried stigmas of Crocus sativus. The structures of new compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of 1, 2, and 3 were unambiguously assigned by the comparison of experimental and calculated ECD data. This is the first report of the isolation of 4 with the HMG moiety from the genus Crocus. Compounds 1 and 4 exhibited weak anti-inflammatory activities on inhibiting lipopolysaccharide (LPS)-induced NO production.
Graphic abstract
中文翻译：
来自番红花柱头的新单萜类化合物
一种新化合物 crocusatin M ( 1 ) 和三种新糖苷化合物 crocusatins NP ( 2-4 ) 以及九种已知化合物从番红花的干燥柱头中分离出来。在光谱分析的基础上阐明了新化合物的结构，并通过比较实验和计算的 ECD 数据明确指定了1、2和3的绝对构型。这是从番红花属中分离出具有 HMG 部分的4的首次报道。化合物1和4对抑制脂多糖（LPS）诱导的NO产生表现出较弱的抗炎活性。
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