Magnetic seizure therapy (MST) has established efficacy in the treatment of depression and a growing evidence base in the treatment of depression. We conducted the first systematic review and meta-analysis of the efficacy of MST in anti-depressive treatment and its impact on cognitive function (INPLASY registration number: INPLASY202170061). We searched for controlled trials published in English between 1 January 2001 to 31 December 2020 in PubMed, EMBASE, Cochrane Library, Web of Science, and PsycINFO databases. The evaluation process strictly followed the Cochrane bias risk assessment tool into the literature, and Meta-analysis was performed according to the Cochrane System Reviewer’s Manual. Data from a total of 285 patients from 10 studies were retained in the quantitative synthesis. The results showed no significant difference between MST and ECT in the antidepressant effect (SDM −0.13 [−0.78;0.52]). Compared with ECT, MST showed shorter recovery time (MD −5.67 [−9.75; −1.60]) and reorientation time (MD −14.67 [−27.96; −1.41]); and MST showed less cognitive impairment on the immediate recall of words (SDM 0.80 [0.35;1.25]), delayed recall of words (SDM 0.99 [0.01;0.74]), visual-spatial immediate memory (SDM 0.51 [0.20;0.83]), visual-spatial delayed memory (SDM 0.57 [0.11;1.02]), and the verbal fluency (SDM 0.51 [0.20;0.83]). Our evidence-based study is the first meta-analysis on the efficacy of MST in anti-depressive treatment and its effect on cognitive function. It showed that the curative effect of MST in anti-depressive treatment is equivalent to that of ECT. Besides, depressive patients with MST benefit more from cognitive function compared with ECT.

磁癫痫疗法 (MST) 已在治疗抑郁症方面确立了疗效，并且在治疗抑郁症方面有越来越多的证据基础。我们对 MST 在抗抑郁治疗中的疗效及其对认知功能的影响进行了首次系统评价和荟萃分析（INPLASY 注册号：INPLASY202170061）。我们在 PubMed、EMBASE、Cochrane 图书馆、Web of Science 和 PsycINFO 数据库中检索了 2001 年 1 月 1 日至 2020 年 12 月 31 日期间以英文发表的对照试验。评价过程严格遵循 Cochrane 偏倚风险评估工具纳入文献，并根据 Cochrane 系统评价者手册进行 Meta 分析。来自 10 项研究的总共 285 名患者的数据被保留在定量合成中。结果显示 MST 和 ECT 在抗抑郁作用方面没有显着差异（SDM -0.13 [-0.78;0.52]）。与ECT相比，MST显示出更短的恢复时间（MD -5.67 [-9.75; -1.60]）和重新定向时间（MD -14.67 [-27.96; -1.41]）；和 MST 在单词的即时回忆 (SDM 0.80 [0.35;1.25])、单词延迟回忆 (SDM 0.99 [0.01;0.74])、视觉空间即时记忆 (SDM 0.51 [0.20;0.83]) 方面表现出较少的认知障碍, 视觉空间延迟记忆 (SDM 0.57 [0.11;1.02]）和语言流畅度（SDM 0.51 [0.20;0.83]）。我们的循证研究是关于 MST 在抗抑郁治疗中的疗效及其对认知功能影响的首次荟萃分析。表明MST在抗抑郁治疗中的疗效与ECT相当。此外，与 ECT 相比，患有 MST 的抑郁症患者从认知功能中获益更多。