Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies.

胃癌是世界上最早的恶性肿瘤之一，每年都有大量的人死于这种疾病。许多遗传和表观遗传风险因素已被确定在胃癌中起主要作用。HOTAIR 是一种有效的表观遗传因子，称为长链非编码 RNA (lncRNA)。HOTAIR 已被描述为通过与许多因素相互作用在生化和细胞过程中具有生物学功能，从而导致基因组稳定性、增殖、存活、侵袭、迁移、转移和耐药性。在本文中，我们回顾了 HOTAIR 调控的分子机制及其在胃癌发展中的作用的预后价值，而阐明 HOTAIR-蛋白质和 HOTAIR-DNA 相互作用有助于识别癌症过程，