Alcohol dehydrogenases have fascinated chemists over the span of a few decades to catalyze oxidation and reduction reactions and have been increasingly incorporated as biocatalysts in scaled-up industrial processes for the production of valuable chiral compounds under mild and environmentally friendly conditions. In this review, we discuss recent advances on alcohol dehydrogenases coupled in cascade reactions with other enzyme classes, chemocatalysts, or organocatalysts to obtain high value–added products. The examples include deracemization processes for the synthesis of chiral diols and amino alcohols, whole-cell and co-expression systems, and chemoenzymatic and organoenzymatic cascades, with a vision for future developments.

在过去的几十年里，醇脱氢酶催化氧化和还原反应引起了化学家的兴趣，并且越来越多地被用作生物催化剂，用于在温和和环境友好的条件下生产有价值的手性化合物的大规模工业过程中。在这篇综述中，我们讨论了醇脱氢酶与其他酶类、化学催化剂或有机催化剂在级联反应中偶联以获得高附加值产品的最新进展。这些例子包括合成手性二醇和氨基醇的去外消旋过程、全细胞和共表达系统，以及化学酶促和有机酶促级联反应，以及对未来发展的展望。