The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a threat to global health because of limited treatments. MRSA infections are difficult to treat due to increasingly developing resistance in combination with protective biofilms of Staphylococcus aureus (S. aureus). Nanotechnology-based research revealed that effective MRSA treatments could be achieved through targeted nanoparticles (NPs) that withstand biological films and drug resistance. Thus, the principal aim towards improving MRSA treatment is to advance drug delivery tools, which successfully address the delivery-related problems. These potential delivery tools would also carry drugs to the desired sites of therapeutic action to overcome the adverse effects. This review focused on different types of nano-engineered carriers system for antimicrobial agents with improved therapeutic efficacy of entrapped drugs. The structural characteristics that play an essential role in the effectiveness of delivery systems have also been addressed with a description of recent scientific advances in antimicrobial treatment, emphasizing challenges in MRSA treatments. Consequently, existing gaps in the literature are highlighted, and reported contradictions are identified, allowing for the development of roadmaps for future research.

由于治疗方法有限，耐甲氧西林金黄色葡萄球菌(MRSA) 的出现已成为对全球健康的威胁。由于越来越多的耐药性与金黄色葡萄球菌( S. aureus) 的保护性生物膜相结合，MRSA 感染难以治疗）。基于纳米技术的研究表明，可以通过耐受生物膜和耐药性的靶向纳米颗粒 (NP) 来实现有效的 MRSA 治疗。因此，改善 MRSA 治疗的主要目标是推进药物递送工具，成功解决与递送相关的问题。这些潜在的递送工具还可以将药物运送到所需的治疗作用部位，以克服不利影响。本综述侧重于不同类型的纳米工程载体系统，用于提高包埋药物治疗效果的抗菌剂。通过描述抗菌治疗的最新科学进展，强调了 MRSA 治疗中的挑战，还讨论了在递送系统的有效性中发挥重要作用的结构特征。