Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network that not only provides mechanical support but also transduces essential molecular signals in organ functions. ECM is constantly remodeled to control tissue homeostasis, responsible for cell adhesion, cell migration, cell-to-cell communication, and cell differentiation, etc. The dysregulation of ECM components contributes to various diseases, including cardiovascular diseases, fibrosis, cancer, and neurodegenerative diseases, etc. Aberrant ECM remodeling is initiated by various stress, such as oxidative stress, inflammation, ischemia, and mechanical stress, etc. Hydrogen sulfide (H₂S) is a gasotransmitter that exhibits a wide variety of cytoprotective and physiological functions through its anti-oxidative and anti-inflammatory actions. Amounting research shows that H₂S can attenuate aberrant ECM remodeling. In this review, we discussed the implications and mechanisms of H₂S in the regulation of ECM remodeling in cardiovascular diseases, and highlighted the potential of H₂S in the prevention and treatment of cardiovascular diseases through attenuating adverse ECM remodeling.

细胞外基质 (ECM) 是一种非细胞的三维大分子网络，不仅提供机械支持，而且在器官功能中转导重要的分子信号。ECM不断被改造以控制组织稳态，负责细胞粘附、细胞迁移、细胞间通讯和细胞分化等。ECM成分的失调导致各种疾病，包括心血管疾病、纤维化、癌症和神经退行性疾病异常的 ECM 重塑是由各种应激引发的，如氧化应激、炎症、缺血和机械应激等。硫化氢 (H ₂S) 是一种气体递质，通过其抗氧化和抗炎作用表现出多种细胞保护和生理功能。大量研究表明，H ₂ S 可以减弱异常的 ECM 重塑。在这篇综述中，我们讨论了H ₂ S 在调节心血管疾病ECM 重构中的意义和机制，并强调了H ₂ S 通过减弱不良ECM 重构在心血管疾病预防和治疗中的潜力。