The cellulose ether and bile salt mixed systems have a potential to alter the lipid digestion. The basic understanding of the aggregation process, interaction, and physicochemical properties of cellulose ether and bile salt is an essential topic of study. In this work, the interaction between simple dietary fiber methylcellulose (MC) and bile salt sodium deoxycholate (NaDC) has been studied using UV-Vis absorption, steady-state fluorescence intensity, fluorescence quenching, conductivity, light scattering, and zeta potential measurements. Fluorescence properties of hydrophobic probe pyrene were used to find the critical aggregation concentration (CAC), critical micellar concentration (CMC), and aggregation number (N_agg) of the MC/NaDC system. Using conventional conductivity method CAC, CMC, and thermodynamic parameters of micellization i.e. standard Gibbs free energy (∆G_mic⁰), standard entropy (∆S_mic⁰), and standard enthalpy (∆H_mic⁰), was calculated to know the information regarding the nature of micellization of MC/NaDC mixed system. The size distribution and zeta potential study give an insight into MC/NaDC interaction before and after the CAC point. The strong hydrophobic interaction between cellulose ether MC and bile salt NaDC shows that this mixed system may have further implications in lipid digestion.

纤维素醚和胆汁盐混合系统有可能改变脂质消化。对纤维素醚和胆汁盐的聚集过程、相互作用和理化性质的基本了解是研究的基本课题。在这项工作中，使用 UV-Vis 吸收、稳态荧光强度、荧光猝灭、电导率、光散射和 zeta 电位测量研究了简单膳食纤维甲基纤维素 (MC) 和胆汁盐脱氧胆酸钠 (NaDC) 之间的相互作用。使用疏水探针芘的荧光特性来计算临界聚集浓度 (CAC)、临界胶束浓度 (CMC) 和聚集数 (N _agg) 的 MC/NaDC 系统。使用传统的电导率方法 CAC、CMC 和胶束化的热力学参数，即标准吉布斯自由能 (Δ G _mic ⁰ )、标准熵 (Δ S _mic ⁰ ) 和标准焓 (Δ H _mic ⁰ )，计算得出信息关于 MC/NaDC 混合体系胶束化的性质。尺寸分布和 zeta 电位研究可以深入了解 CAC 点之前和之后的 MC/NaDC 相互作用。纤维素醚 MC 和胆汁盐 NaDC 之间的强疏水相互作用表明，这种混合系统可能对脂质消化有进一步的影响。