Objectives

There is growing evidence highlighting the role of environmental risk factors of NMO-IgG seropositivity in patients with neuromyelitis optica spectrum disorder (NMOSD). The present study investigated the possible association between dietary total antioxidant capacity (TAC) and NMO-IgG seropositivity in NMOSD patients.

Methods

Fifty-six patients with a definite diagnosis of NMOSD were included in the study. Data on patients’ age, gender, height, weight, cigarette smoking status, and alcohol consumption were collected and recorded. Body mass index (BMI) was also calculated. In addition, dietary habits of patients were evaluated using an adjusted semi-quantitative food frequency questionnaire (FFQ) that consists of 168 food items. Dietary TAC was calculated using the oxygen radical absorption capacity (ORAC) method. Enzyme-linked immunosorbent assay (ELISA) method was used to determine the NMO-IgG serum status. The association between dietary TAC and odds of NMO-IgG seropositivity was measured using the logistic regression analysis.

Results

The mean of dietary TAC was 8362.8 (μmolTE/1000 kcal) in seronegative patients and 6609.9 (μmolTE/1000 kcal) in seropositive patients and had a significant difference between the mentioned groups of patients (P: 0.02). An inverse association was found between dietary TAC and odds of NMO-IgG seropositivity in all three regression models. The higher dietary intake of antioxidant resulted in significant findings as follows: 92% (95% CI: 0.01–0.53), 97% (95% CI: 0.00–0.34), and 97% (95% CI: 0.00–0.32) lower odds of NMO-IgG seropositivity in the fourth quartiles of the first, the second, and the third regression model, respectively. Moreover, the inverse association between fruit intake and odds of NMO-IgG seropositivity was significant in the third quartile (OR:0.10; 95%CI: 0.01–0.97).

Conclusion

The present study indicated a significant inverse association between dietary TAC and NMO-IgG seropositivity of NMOSD patients. As no definite treatment can be offered for NMOSD and nutrition is a modifiable factor in this regard, specification of dietary factors affecting the risk of NMOSD is of great value.

中文翻译：

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视神经脊髓炎谱系障碍患者膳食总抗氧化能力与 NMO-IgG 血清学阳性的关系

目标

越来越多的证据强调 NMO-IgG 血清学阳性的环境危险因素在视神经脊髓炎谱系障碍 (NMOSD) 患者中的作用。本研究调查了 NMOSD 患者膳食总抗氧化能力 (TAC) 与 NMO-IgG 血清学阳性之间可能存在的关联。

方法

56 名确诊为 NMOSD 的患者被纳入研究。收集并记录患者年龄、性别、身高、体重、吸烟状况和饮酒量的数据。还计算了体重指数（BMI）。此外，使用由 168 种食物组成的调整后的半定量食物频率问卷 (FFQ) 评估患者的饮食习惯。膳食 TAC 使用氧自由基吸收能力 (ORAC) 方法计算。酶联免疫吸附试验（ELISA）方法用于确定NMO-IgG血清状态。使用逻辑回归分析测量膳食 TAC 与 NMO-IgG 血清学阳性几率之间的关联。

结果

血清阴性患者的膳食 TAC 平均值为 8362.8（μmolTE/1000 kcal），血清阳性患者为 6609.9（μmolTE/1000 kcal），在上述患者组之间有显着差异（P：0.02）。在所有三个回归模型中，发现膳食 TAC 与 NMO-IgG 血清学阳性几率之间存在负相关。较高的抗氧化剂膳食摄入量导致以下显着发现：92% (95% CI: 0.01–0.53)、97% (95% CI: 0.00–0.34) 和 97% (95% CI: 0.00–0.32) 降低分别在第一、第二和第三回归模型的第四四分位数中 NMO-IgG 血清阳性的几率。此外，水果摄入量与 NMO-IgG 血清学阳性几率之间的负相关在第三个四分位数中显着（OR：0.10；95%CI：0.01-0.97）。

结论

本研究表明 NMOSD 患者的膳食 TAC 与 NMO-IgG 血清学阳性之间存在显着的负相关。由于无法为 NMOSD 提供明确的治疗方法，并且在这方面营养是一个可改变的因素，因此说明影响 NMOSD 风险的饮食因素具有重要价值。