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Enhancement of self-sustained muscle activity through external dead space ventilation appears to be associated with hypercapnia
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-08-21 , DOI: 10.1016/j.resp.2021.103777
Kei Hatano 1 , Ryouta Matsuura 2 , Yoshinori Ohtsuka 3 , Takahiro Yunoki 4
Affiliation  

We reported that external dead space ventilation (EDSV) enhanced self-sustained muscle activity (SSMA) of the human soleus muscle, which is an indirect observation of plateau potentials. However, the main factor for EDSV to enhance SSMA remains unclear. The purpose of the present study was to examine the effects of EDSV-induced hypercapnia, hypoxia, and hyperventilation on SSMA. In Experiment 1 (n = 11; normal breathing [NB], EDSV, hypoxia, and voluntary hyperventilation conditions) and Experiment 2 (n = 9; NB and normoxic hypercapnia [NH] conditions), SSMA was evoked by electrical train stimulations of the right tibial nerve and measured using surface electromyography under each respiratory condition. In Experiment 1, SSMA was significantly higher than that in the NB condition only in the EDSV condition (P < 0.05). In Experiment 2, SSMA was higher in the NH condition than in the NB condition (P < 0.05). These results suggest that the EDSV-enhanced SSMA is due to hypercapnia, not hypoxia or increased ventilation.



中文翻译:

通过外部死腔通气增强自我维持的肌肉活动似乎与高碳酸血症有关

我们报道了外部死腔通气 (EDSV) 增强了人类比目鱼肌的自我维持肌肉活动 (SSMA),这是对平台电位的间接观察。然而,EDSV 增强 SSMA 的主要因素仍不清楚。本研究的目的是检查 EDSV 引起的高碳酸血症、缺氧和过度换气对 SSMA 的影响。在实验 1n = 11;正常呼吸 [NB]、EDSV、缺氧和自愿过度换气条件)和实验 2n = 9;NB 和常氧高碳酸血症 [NH] 条件)中,SSMA 由右胫神经,并在每种呼吸条件下使用表面肌电图测量。实验1,仅在EDSV条件下,SSMA显着高于NB条件(P <0.05)。在实验 2中,NH 条件下的 SSMA 高于 NB 条件下(P < 0.05)。这些结果表明 EDSV 增强的 SSMA 是由于高碳酸血症,而不是缺氧或通气增加。

更新日期:2021-08-29
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