The microwave-assisted 1,3-dipolar cycloaddition of furanyl and benzyl oximes and several methyl acrylates effectively provided several isoxazoline when mediated by diacetoxyiodobenzene. The selected isoxazoline, methyl-5-(3-methoxy-3-oxopropyl)-3-phenyl-4,5-dihydro isoxazole-5-carboxylate, was rapidly transformed to the γ-lactone carboxylic acid, 2-(2-amino-2-phenylethyl)-5-oxotetrahydrofuran-2-carboxylic acid, in reasonable yield. The biological activity of this γ-lactone carboxylic acid increased the growth of E. coli organisms by about 44% and has a potential significance in stem cell research.

中文翻译：

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2-(2-氨基-2-苯乙基)-5-氧代四氢呋喃-2-羧酸的合成和生物活性：微波辅助的 1,3-偶极环加成方法

当由二乙酰氧基碘苯介导时，呋喃基和苄基肟以及几种丙烯酸甲酯的微波辅助 1,3-偶极环加成有效地提供了几种异恶唑啉。选定的异恶唑啉，甲基-5-(3-甲氧基-3-氧代丙基)-3-苯基-4,5-二氢异恶唑-5-羧酸酯迅速转化为 γ-内酯羧酸，2-(2-氨基-2-苯基乙基)-5-氧代四氢呋喃-2-羧酸，产率合理。这种 γ-内酯羧酸的生物活性使大肠杆菌生物体的生长增加了约 44%，在干细胞研究中具有潜在意义。