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An Efficient Protocol for the Synthesis of Pyrazolo[1,5-c]quinazolines by a Staudinger–Aza-Wittig–Dehydroaromatization Sequence
Synlett ( IF 1.7 ) Pub Date : 2021-08-05 , DOI: 10.1055/a-1579-1692
Zhilin Ren , Ping He , Mingxian Xu , An Chen , Jiying Qiu , Mingming Zu , Yi Zhang , Jiayi Wang

The one-pot synthesis of azide-substituted dihydropyrazoles in isopropanol was performed by using chalcones, hydrazine hydrate, and an acyl chloride at 0 ℃. Subsequent Staudinger–aza-Wittig–dehydroaromatization reactions of the products with methyl(diphenyl)phosphine were also investigated for further application in the construction of pyrazolo[1,5-c]quinazolines.

中文翻译:

通过施陶丁格-Aza-Wittig-脱氢芳构化序列合成吡唑并[1,5-c]喹唑啉的有效方案

以查耳酮、水合肼和酰氯为原料,在0 ℃下在异丙醇中一锅法合成叠氮化物取代的二氢吡唑类化合物。还研究了产物与甲基(二苯基)膦的后续 Staudinger-aza-Wittig-脱氢芳构化反应,以进一步应用于构建吡唑并 [1,5-c] 喹唑啉。
更新日期:2021-08-21
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