Abstract

Osteoimmunology has emerged as a field linking immunology and bone biology, but it has yet to be recognized as belonging to mainstream immunology. However, the extent of the research fields immunology actually covers has been enormously widened, and it is now ready to include such an interdisciplinary subject. One of the most obvious examples of an interaction between the immune and bone systems is the pathogenesis of rheumatoid arthritis, where bone resorption is increased by the autoimmune response. Moreover, the regulation of the immune system by bone cells has been clearly demonstrated by the finding that osteoprogenitor cells contribute to hematopoietic stem cell maintenance as well as the suppression of hematopoietic malignancy. Thus, the bidirectional dialogue has been established and inevitably will lead to the union of bone and immunity. Here I summarize the history and concept of osteoimmunology, providing a perspective on the future of immunology.

中文翻译：

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骨免疫学作为免疫学的内在组成部分

摘要

骨免疫学已成为连接免疫学和骨生物学的领域，但尚未被认为属于主流免疫学。然而，免疫学实际涵盖的研究领域的范围已经大大拓宽，现在已经准备好纳入这样一个跨学科的学科。免疫系统和骨骼系统之间相互作用的最明显例子之一是类风湿性关节炎的发病机制，其中自身免疫反应会增加骨吸收。此外，骨祖细胞有助于造血干细胞维持以及抑制造血恶性肿瘤的发现清楚地证明了骨细胞对免疫系统的调节。这样，双向对话就建立起来了，必然会导致骨骼与免疫的结合。