To the Editor—The recent article by Sharwani et al [1] demonstrated cross-reactive immunological memory between betacoronavirus spike and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children and young adults. Another recent study, in older adults, found a correlation between lower levels of anti-human coronavirus (HCoV) OC43-specific antibodies and risk for severe coronavirus disease 2019 (COVID-19) [2]. These and other studies [3] point towards a potential benefit for immune cross-reactivity among SARS-CoV-2 and seasonal coronaviruses. However, Anderson et al reported that antibodies cross-reacting to SARS-CoV-2 proteins elicited by seasonal human betacoronaviruses did not prevent COVID-19 [4], a finding that was also shared by Gombar et al who, in addition, did not find that a prior infection by seasonal coronavirus modulated the severity of COVID-19 [5]. While the net effect of prior betacoronavirus infection upon COVID-19 severity is yet to be elucidated, we cannot help but wonder if, and how, will SARS-CoV-2 impact future infections by other coronaviruses.

中文翻译：

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SARS-CoV-2 感染和疫苗接种后的季节性冠状病毒肺炎：新的敌人？

致编辑— Sharwani 等人最近的文章 [1] 证明了儿童和年轻人中 β 冠状病毒尖峰和严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 之间的交叉反应性免疫记忆。最近在老年人中进行的另一项研究发现，较低水平的抗人类冠状病毒 (HCoV) OC43 特异性抗体与 2019 年严重冠状病毒病 (COVID-19) 的风险之间存在相关性 [2]。这些和其他研究 [3] 指出了 SARS-CoV-2 和季节性冠状病毒之间免疫交叉反应的潜在益处。然而，Anderson 等人报告说，与季节性人类 β 冠状病毒引发的 SARS-CoV-2 蛋白发生交叉反应的抗体并不能预防 COVID-19 [4]，Gombar 等人也分享了这一发现，此外，没有发现季节性冠状病毒的先前感染会调节 COVID-19 的严重程度 [5]。虽然尚未阐明先前感染 β 冠状病毒对 COVID-19 严重程度的净影响，但我们不禁想知道 SARS-CoV-2 是否以及如何影响其他冠状病毒的未来感染。