The TNF superfamily member a proliferation inducing ligand (APRIL, TNFSF13) plays a late role in humoral immunity at the level of antibody-producing plasmocytes. The recent characterization of the first immunodeficient patient with an inactivating mutation in the APRIL gene provided the last piece of functional data lacking in the human system. Based on this function, APRIL has been considered as a valuable target to dampen unwanted antibody production. After reviewing the late data acquired on the physiological function of APRIL in humoral immunity, we will here review the state of the art regarding APRIL targeting in autoimmune diseases.

中文翻译：

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该家族的第 13 号：增殖诱导配体。

TNF超家族成员增殖诱导配体（APRIL，TNFSF13）在产生抗体的浆细胞水平的体液免疫中起后期作用。最近对第一个在 APRIL 基因中具有失活突变的免疫缺陷患者的表征提供了人类系统缺乏的最后一条功能数据。基于此功能，APRIL 被认为是抑制不需要的抗体产生的有价值的目标。在回顾了有关 APRIL 在体液免疫中的生理功能的最新数据后，我们将在此回顾有关 APRIL 靶向自身免疫性疾病的最新技术。