BACKGROUND Parkinson’s disease is the second most common neurodegenerative condition and associated with increasing cognitive dysfunction as the disease progresses. However, subtle cognitive deficits can be detected at diagnosis in 42% of individuals, suggesting that damage may already be present. Our aim was to determine clinical and structural differences in those recently diagnosed with PD who later develop cognitive impairment, and whether these changes predict future cognitive decline.

中文翻译：

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使用临床数据和结构 MRI 预测新发帕金森病的未来认知障碍

背景帕金森病是第二种最常见的神经退行性疾病，并且随着疾病的进展与认知功能障碍的增加有关。然而，42% 的个体在诊断时可以检测到细微的认知缺陷，这表明损伤可能已经存在。我们的目的是确定最近诊断为 PD 且后来发展为认知障碍的患者的临床和结构差异，以及这些变化是否预示着未来的认知能力下降。