Purpose To evaluate the association between body mass index (BMI) and clinical outcomes other than death in patients hospitalised and intubated with COVID-19. Methods This is a single-centre cohort study of adults with COVID-19 admitted to New York Presbyterian Hospital-Weill Cornell Medicine from 3 March 2020 through 15 May 2020. Baseline and outcome variables, as well as lab and ventilatory parameters, were generated for the admitted and intubated cohorts after stratifying by BMI category. Linear regression models were used for continuous, and logistic regression models were used for categorical outcomes. Results The study included 1337 admitted patients with a subset of 407 intubated patients. Among admitted patients, hospital length of stay (LOS) and home discharge was not significantly different across BMI categories independent of demographic characteristics and comorbidities. In the intubated cohort, there was no difference in in-hospital events and treatments, including renal replacement therapy, neuromuscular blockade and prone positioning. Ventilatory ratio was higher with increasing BMI on days 1, 3 and 7. There was no significant difference in ventilator free days (VFD) at 28 or 60 days, need for tracheostomy, hospital LOS, and discharge disposition based on BMI in the intubated cohort after adjustment. Conclusions In our COVID-19 population, there was no association between obesity and morbidity outcomes, such as hospital LOS, home discharge or VFD. Further research is needed to clarify the mechanisms underlying the reported effects of BMI on outcomes, which may be population dependent. Data are available upon reasonable request.

中文翻译：

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COVID-19住院患者体重指数与发病率的关系

目的 评估 COVID-19 住院和插管患者的体重指数 (BMI) 与除死亡以外的临床结局之间的关联。方法 这是一项单中心队列研究，对象为 2020 年 3 月 3 日至 2020 年 5 月 15 日在纽约长老会医院-威尔康奈尔医学中心收治的 COVID-19 成人患者。为按 BMI 类别分层后的入院和插管队列。线性回归模型用于连续，逻辑回归模型用于分类结果。结果 该研究包括 1337 名入院患者和 407 名插管患者。在入院患者中，与人口学特征和合并症无关的 BMI 类别的住院时间 (LOS) 和出院时间没有显着差异。在插管队列中，住院事件和治疗没有差异，包括肾脏替代治疗、神经肌肉阻滞和俯卧位。在第 1、3 和 7 天，随着 BMI 的增加，通气比率更高。在插管队列中，28 天或 60 天的无呼吸机天数 (VFD)、气管切开术的需要、医院 LOS 和基于 BMI 的出院处置没有显着差异调整后。结论 在我们的 COVID-19 人群中，肥胖与发病结果之间没有关联，例如医院 LOS、出院或 VFD。需要进一步的研究来阐明 BMI 对结果的报告影响的机制，这可能取决于人群。可根据合理要求提供数据。