Primary cilia are solitary, microtubule-based structures emanating from the surface of most vertebrate cells. Although it is understood that ciliary assembly and disassembly both depend upon and impact cell cycle progression, critical mechanistic details of these links remain unresolved. Accumulating evidence shows that the signaling pathways downstream of receptor tyrosine kinases and lysophosphatidic acid receptors control the dynamics of primary cilia. It has also become clear that primary cilia not only serve as signaling hubs but also regulate the composition of the surrounding membrane, which is likely to affect the response to growth factors. Here, we overview recent advances in understanding the interplay between primary cilia and the cell cycle, with a focus on growth factor signaling pathways.

初级纤毛是从大多数脊椎动物细胞表面发出的孤立的、基于微管的结构。尽管可以理解纤毛组装和拆卸都依赖并影响细胞周期进程，但这些联系的关键机制细节仍未解决。越来越多的证据表明受体酪氨酸激酶和溶血磷脂酸受体下游的信号通路控制初级纤毛的动力学。还很清楚的是，初级纤毛不仅充当信号枢纽，而且还调节周围膜的组成，这可能会影响对生长因子的反应。在这里，我们概述了了解初级纤毛和细胞周期之间相互作用的最新进展，重点是生长因子信号通路。