The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, are not well understood. Here, we review evidence from clinical trials about the benefits and risks of SSRIs in young people and consider their mechanisms of action, as shown through human experimental work and animal models. We emphasise key outstanding questions about the effects of SSRIs in youth, identified through gaps in the literature and in consultation with young people with lived experience. It is crucial to characterise the mechanisms underpinning risks and benefits of SSRIs in this age group to progress the field, and to narrow the chasm between the widespread use of SSRIs in youth and the science on which this use is based.

SSRIs 用于治疗年轻人的抑郁症和焦虑症的情况正在增加。然而，SSRIs 在青春期（神经、认知和社会功能发生重大变化的时期）的影响尚不清楚。在这里，我们回顾了关于 SSRI 对年轻人的益处和风险的临床试验证据，并考虑了它们的作用机制，如通过人体实验工作和动物模型所示。我们强调关于 SSRIs 对青年的影响的关键突出问题，这些问题是通过文献中的空白和与有生活经验的年轻人协商确定的。描述支持该年龄组 SSRI 的风险和益处的机制以推动该领域的发展至关重要，