当前位置：
X-MOL 学术
›
J. Nutr. Biochem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Kaempferol reduces obesity, prevents intestinal inflammation, and modulates gut microbiota in high-fat diet mice
The Journal of Nutritional Biochemistry ( IF 4.8 ) Pub Date : 2021-08-20 , DOI: 10.1016/j.jnutbio.2021.108840 Yifei Bian 1 , Jiaqi Lei 2 , Jia Zhong 3 , Bo Wang 2 , Yan Wan 2 , Jinxin Li 3 , Chaoyong Liao 2 , Yang He 2 , Zhongjie Liu 3 , Koichi Ito 4 , Bingkun Zhang 2
The Journal of Nutritional Biochemistry ( IF 4.8 ) Pub Date : 2021-08-20 , DOI: 10.1016/j.jnutbio.2021.108840 Yifei Bian 1 , Jiaqi Lei 2 , Jia Zhong 3 , Bo Wang 2 , Yan Wan 2 , Jinxin Li 3 , Chaoyong Liao 2 , Yang He 2 , Zhongjie Liu 3 , Koichi Ito 4 , Bingkun Zhang 2
Affiliation
|
Kaempferol, a flavonoid identified in a wide variety of dietary sources, has been reported to possess anti-obesity properties; however, its underlying mechanism was poorly understood. Chronic, low-grade gut inflammation and dysbacteria are proposed as underlying factors as well as novel treatment approaches for obesity-associated pathologies. This present study aims to investigate the benefits of experimental treatment with kaempferol on intestinal inflammation and gut microbial balance in animal model of obesity. High fat diet (HFD) was applied to C57BL/6J mice for 16 weeks, during which the supplement of kaempferol served as a variable. Clearly, HFD induced obesity, fat accumulation, glucose intolerance and adipose inflammation, the metabolic syndrome of which was the main finding. All these metabolic disorders can be alleviated through kaempferol supplementation. In addition, increased intestinal permeability, infiltration of immunocytes (macrophage, dendritic cells and neutrophils) and overexpression of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1) were also found in the HFD-induced mice. Kaempferol supplementation improved intestinal barrier integrity and inhibited gut inflammation, by reducing the activation of TLR4/NF-κB pathway. Furthermore, the characterization of the cecal microbiota by sequencing showed that kaempferol supplementation was able to counteract the dysbiosis associated to obesity. Our study delineated the multiple mechanism of action underlying the anti-obesity effect of kaempferol, and provide scientific evidence to support the development of kaempferol as a dietary supplement for obesity treatment.
中文翻译：
山奈酚可减少高脂肪饮食小鼠的肥胖、预防肠道炎症并调节肠道微生物群
山奈酚是一种在多种膳食来源中发现的黄酮类化合物，据报道具有抗肥胖特性。然而，人们对其基本机制知之甚少。慢性、低度肠道炎症和菌群失调被认为是肥胖相关病理的潜在因素以及新的治疗方法。本研究旨在探讨山奈酚实验治疗对肥胖动物模型肠道炎症和肠道微生物平衡的益处。 C57BL/6J小鼠采用高脂饮食（HFD）16周，在此期间补充山奈酚作为变量。显然，高脂饮食会导致肥胖、脂肪堆积、葡萄糖不耐症和脂肪炎症，其中代谢综合征是主要发现。所有这些代谢紊乱都可以通过补充山奈酚来缓解。此外，HFD 中还发现肠道通透性增加、免疫细胞（巨噬细胞、树突状细胞和中性粒细胞）浸润以及炎症细胞因子（肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、单核细胞趋化蛋白-1）过度表达。诱导小鼠。补充山奈酚可通过减少 TLR4/NF-κB 通路的激活来改善肠道屏障完整性并抑制肠道炎症。此外，通过测序对盲肠微生物群的表征表明，补充山奈酚能够抵消与肥胖相关的菌群失调。我们的研究阐明了山奈酚抗肥胖作用的多种作用机制，并为支持山奈酚作为肥胖治疗膳食补充剂的开发提供了科学证据。
更新日期：2021-08-20
中文翻译：
山奈酚可减少高脂肪饮食小鼠的肥胖、预防肠道炎症并调节肠道微生物群
山奈酚是一种在多种膳食来源中发现的黄酮类化合物，据报道具有抗肥胖特性。然而，人们对其基本机制知之甚少。慢性、低度肠道炎症和菌群失调被认为是肥胖相关病理的潜在因素以及新的治疗方法。本研究旨在探讨山奈酚实验治疗对肥胖动物模型肠道炎症和肠道微生物平衡的益处。 C57BL/6J小鼠采用高脂饮食（HFD）16周，在此期间补充山奈酚作为变量。显然，高脂饮食会导致肥胖、脂肪堆积、葡萄糖不耐症和脂肪炎症，其中代谢综合征是主要发现。所有这些代谢紊乱都可以通过补充山奈酚来缓解。此外，HFD 中还发现肠道通透性增加、免疫细胞（巨噬细胞、树突状细胞和中性粒细胞）浸润以及炎症细胞因子（肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、单核细胞趋化蛋白-1）过度表达。诱导小鼠。补充山奈酚可通过减少 TLR4/NF-κB 通路的激活来改善肠道屏障完整性并抑制肠道炎症。此外，通过测序对盲肠微生物群的表征表明，补充山奈酚能够抵消与肥胖相关的菌群失调。我们的研究阐明了山奈酚抗肥胖作用的多种作用机制，并为支持山奈酚作为肥胖治疗膳食补充剂的开发提供了科学证据。
京公网安备 11010802027423号