Despite being rare, primary ovarian insufficiency (POI) is a significant cause of infertility and deficiency of ovarian hormone in women. Several health risks are also associated with POI, which include dry eye syndrome, reduced density of bones and enhanced fracture risks, troublesome menopausal symptoms, early development of cardiovascular disease, and psychological effects such as declined cognition, reduced perceived psychological support, anxiety, and depression. Replacing premenopausal levels of ovarian sex steroids through proper hormone replacement therapy could improve the quality of life for POI women and ameliorate related health risks. Herein, POI and its complications, in addition to hormone replacement therapies, which are safe and effective, are discussed. It is proposed that the use of HRT) Hormone replacement therapy (formulations which mimic normal production of ovarian hormones could reduce POI-associated morbidity rates if they are continued by the age 50, which is approximately the natural age of menopause. Particular populations of POI women are also addressed, which include those with enhanced risk of ovarian or breast cancer, those with Turner syndrome, those approaching natural menopause, and those who are breastfeeding. It is generally predicted that stem cell-based therapies would be both safe and effective. In fact, several types of cells have been described as safe, though their effectiveness and therapeutic application are yet to be defined. Several factors exist which could affect the results of treatment, such as cell handling, ex-vivo preparation strategies, variations in tissue of origin, potency, and immunocompatibility. Accordingly, cell types potentially effective in regenerative medicine could be recognized. Notably, products of MSCs from various sources of tissues show different levels of regenerative capabilities. The ultimate focus of the review is on adipose tissue-derive MCSs (ADMSCs), which possess exceptional features such as general availability, great ability to proliferate and differentiate, immunomodulatory capabilities, and low immunogenicity.

尽管很少见，但原发性卵巢功能不全 (POI) 是女性不孕和卵巢激素缺乏的重要原因。一些健康风险也与 POI 相关，包括干眼症、骨骼密度降低和骨折风险增加、令人烦恼的更年期症状、心血管疾病的早期发展以及认知能力下降、感知心理支持减少、焦虑和焦虑等心理影响。沮丧。通过适当的激素替代疗法替代绝经前水平的卵巢性类固醇可以改善 POI 女性的生活质量并改善相关的健康风险。在此，除了安全有效的激素替代疗法外，还讨论了 POI 及其并发症。组织起源、效力和免疫相容性的差异。因此，可以识别在再生医学中可能有效的细胞类型。值得注意的是，来自不同组织来源的 MSCs 产品显示出不同水平的再生能力。审查的最终重点是脂肪组织衍生的 MCS (ADMSC)，它具有特殊的特性，如普遍可用性、强大的增殖和分化能力、免疫调节能力和低免疫原性。