Objectives

To investigate in singleton multiparous pregnancies the effect of having a new father for an index pregnancy on new-borns’ birthweights and intrauterine growth restriction.

Design

20 year-observational cohort study (2001–2020).

Settings

Centre Hospitalier Universitaire Hospitalier Sud Reunion’s maternity (French overseas department, Indian Ocean).

Main outcomes and measures

Comparing the 811 multiparas (cases) who had a new partner with the 49,712 who did not (controls), there were no differences concerning maternal age, education, ovulation induction/IVF, previous miscarriages, exams during pregnancies, pre-pregnancy BMI, gestational diabetes, and chronic hypertension. Cases had more previous pregnancies than controls (gravidity 4.2 vs 2.8, p < 0.001), volunteer abortions (OR1.93, p < 0.001), in vitro fecundations (OR 4.34, p < 0.001), were more likely to be unmarried (OR 2.94, p < 0.001) smoker (OR 2.2, p < 0.0001) and consuming alcohol during pregnancy (OR 2.35, p = 0.001). Cases had a much higher risk of preeclampsia than controls (OR 3.94, p < 0.001), especially early-onset preeclampsia (< 34 weeks) with an OR 4.1 (p < 0.001). Controlling for confounding factors (preeclampsia, smoking, alcohol use, early prematurity < 33 weeks, maternal ethnicity), primipaternity was an independent factor for small for gestational age newborns (OR 1.48, p < 0.001).

Conclusions

It has been known for decades that primiparas have lighter babies than multiparas. Primipaternity represents also a risk for lower birth weights. Human birthweight seems to be linked with a “couple habituation” (to paternal genes) which may be not fully established in the first pregnancy of the couple.

中文翻译：

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初产妇和人类出生体重

目标

调查单胎多胎妊娠中新父亲对新生儿出生体重和宫内生长受限的影响。

设计

20 年观察性队列研究（2001-2020）。

设置

Center Hospitalier Universitaire Hospitalier Sud Reunion 的产科（法国海外部，印度洋）。

主要成果和措施

将有新伴侣的 811 例（病例）与没有新伴侣的 49,712 例（对照）进行比较，在产妇年龄、教育程度、排卵诱导/IVF、既往流产、怀孕期间的检查、孕前 BMI、妊娠期检查等方面没有差异。糖尿病和慢性高血压。与对照组相比，病例的既往妊娠次数（妊娠率 4.2 与 2.8，p < 0.001）、自愿堕胎（OR1.93，p < 0.001）、体外受精（OR 4.34，p < 0.001）、未婚可能性更大（OR 2.94, p < 0.001) 吸烟者 (OR 2.2, p < 0.0001) 和怀孕期间饮酒 (OR 2.35, p = 0.001)。与对照组相比，病例发生先兆子痫的风险要高得多（OR 3.94，p < 0.001），尤其是早发性先兆子痫（<34 周），OR 为 4.1（p < 0.001）。控制混杂因素（先兆子痫、吸烟、

结论

几十年来，众所周知，初产妇的婴儿比经产妇更轻。初产妇也代表了较低出生体重的风险。人类出生体重似乎与“夫妻习惯化”（与父系基因有关）有关，这在夫妻第一次怀孕时可能尚未完全确定。