The exhaustive exploration of the conventional synthetic approaches for the synthesis of nitrogen and sulphur containing heterocyclic moieties has diverted the attention of researchers towards novel eco-friendly strategies of these compounds. Several green chemistry-based synthetic methods like multi-component single pot reaction, recyclable green-based catalyst, green solvent, reusable solvent, ultrasound-mediated synthesis, the solvent-free and microwave-assisted technique have been developed for the synthesis of thiazole derivatives with anticancer potential. According to the cancer society, almost 14.1 million cancer cases and about 8.2 million deaths due to cancer have been reported, which implies that one of every seven deaths occurs due to cancer disease. The thiazole scaffold is contained in more than 18 FDA-approved drugs, as well as, in several experimental formulations. Among them, alpelisib, a thiazole-based drug with the brand name Pigray®, was approved in 2019 for the treatment of breast cancer. The goal of the present review is to highlight the recent advancements in the green chemistry-based synthesis of thiazole derivatives with the discussion of their structure-activity relationship. Based on innovative eco-friendly reports in synthetic literature, this paper compiled the green strategies-based development of thiazole derivatives from 2012 till now with effective anticancer potential.

对合成含氮和硫杂环部分的常规合成方法的详尽探索已将研究人员的注意力转移到这些化合物的新型环保策略上。开发了多组分单锅反应、可回收绿色基催化剂、绿色溶剂、可重复使用溶剂、超声介导合成、无溶剂和微波辅助技术等几种绿色化学合成方法用于合成噻唑衍生物具有抗癌潜力。根据癌症协会的统计，已报告了近 1410 万例癌症病例和约 820 万例癌症死亡病例，这意味着每 7 例死亡中就有 1 例死于癌症疾病。噻唑支架包含在超过 18 种 FDA 批准的药物中，以及，在几个实验配方中。其中，alpelisib 是一种商品名为 Pigray® 的噻唑类药物，于 2019 年获批用于治疗乳腺癌。本综述的目的是强调基于绿色化学的噻唑衍生物合成的最新进展，并讨论它们的构效关系。本文基于合成文献中创新的环保报告，整理了2012年至今具有有效抗癌潜力的噻唑衍生物的绿色发展策略。本综述的目的是强调基于绿色化学的噻唑衍生物合成的最新进展，并讨论它们的构效关系。本文基于合成文献中创新的环保报告，整理了2012年至今具有有效抗癌潜力的噻唑衍生物的绿色发展策略。本综述的目的是强调基于绿色化学的噻唑衍生物合成的最新进展，并讨论它们的构效关系。本文基于合成文献中创新的环保报告，整理了2012年至今具有有效抗癌潜力的噻唑衍生物的绿色发展策略。