Multifunctional Biodegradable Prussian Blue Analogue for Synergetic Photothermal/Photodynamic/Chemodynamic Therapy and Intrinsic Tumor Metastasis Inhibition,ACS Applied Bio Materials

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Multifunctional Biodegradable Prussian Blue Analogue for Synergetic Photothermal/Photodynamic/Chemodynamic Therapy and Intrinsic Tumor Metastasis Inhibition
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-08-19 , DOI: 10.1021/acsabm.1c00694
Yuting Hao ₁ , Lianzhi Mao ₁ , Rongjun Zhang ₂ , Xiaoshan Liao ₁ , Miaomiao Yuan ₃ , Wenzhen Liao ₁

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To date, various Prussian blue analogues (PBAs) have been prepared for biomedical applications due to their unique structural advantages. However, the safety and effectiveness of tumor treatment still need further exploration. This contribution reports a facile synthesis of PBA with superior tumor synergetic therapeutic effects and a detailed mechanistic evaluation of their intrinsic tumor metastasis inhibition activity. The as-synthesized PBA has a uniform cube structure with a diameter of approximately 220 nm and shows high near-infrared light (NIR) photoreactivity, photothermal conversion efficiency (41.44%), and photodynamic effect. Additionally, PBA could lead to a chemodynamic effect, which is caused by the Fenton reaction and ferroptosis. The combined therapy strategy of PBA exhibits notable tumor ablation properties due to photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) effects without obvious toxicity in vivo. The PBA has also shown potential as a contrast agent for magnetic resonance imaging (MRI) and photoacoustic (PA) imaging. More importantly, careful investigations reveal that PBA displays excellent biodegradation and anti-metastasis properties. Further exploration of the PBA implies that its underlying mechanism of intrinsic tumor metastasis inhibition activity can be attributed to the modulation of epithelial–mesenchymal transition (EMT) expression. The considerable potential exhibited by the as-synthesized PBA makes it an ideal candidate as a synergetic therapeutic agent for tumor treatment.

中文翻译：

用于协同光热/光动力/化学动力治疗和内在肿瘤转移抑制的多功能可生物降解普鲁士蓝类似物

迄今为止，由于其独特的结构优势，各种普鲁士蓝类似物（PBA）已被制备用于生物医学应用。然而，肿瘤治疗的安全性和有效性仍需进一步探索。该贡献报告了具有优异肿瘤协同治疗效果的 PBA 的简便合成和对其内在肿瘤转移抑制活性的详细机制评估。合成后的 PBA 具有均匀的立方体结构，直径约为 220 nm，具有高近红外 (NIR) 光反应性、光热转换效率 (41.44%) 和光动力效应。此外，PBA 可能导致由芬顿反应和铁死亡引起的化学动力学效应。在体内。PBA 还显示出作为磁共振成像 (MRI) 和光声 (PA) 成像的造影剂的潜力。更重要的是，仔细研究表明，PBA 具有出色的生物降解和抗转移特性。对 PBA 的进一步探索意味着其内在肿瘤转移抑制活性的潜在机制可归因于上皮-间质转化 (EMT) 表达的调节。合成后的 PBA 表现出的巨大潜力使其成为肿瘤治疗协同治疗剂的理想候选者。

更新日期：2021-09-20

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