Fatty acid metabolism is known to support tumorigenesis and disease progression as well as treatment resistance through enhanced lipid synthesis, storage and catabolism. More recently, the role of membrane fatty acid composition, for example, ratios of saturated, monounsaturated and polyunsaturated fatty acids, in promoting cell survival while limiting lipotoxicity and ferroptosis has been increasingly appreciated. Alongside these insights, it has become clear that tumour cells exhibit plasticity with respect to fatty acid metabolism, responding to extratumoural and systemic metabolic signals, such as obesity and cancer therapeutics, to promote the development of aggressive, treatment-resistant disease. Here, we describe cellular fatty acid metabolic changes that are connected to therapy resistance and contextualize obesity-associated changes in host fatty acid metabolism that likely influence the local tumour microenvironment to further modify cancer cell behaviour while simultaneously creating potential new vulnerabilities.

已知脂肪酸代谢通过增强脂质合成、储存和分解代谢来支持肿瘤发生和疾病进展以及治疗抗性。最近，膜脂肪酸组成的作用，例如饱和、单不饱和和多不饱和脂肪酸的比例，在促进细胞存活同时限制脂毒性和铁死亡中的作用越来越受到重视。除了这些见解外，很明显肿瘤细胞在脂肪酸代谢方面表现出可塑性，对肿瘤外和全身代谢信号（如肥胖和癌症治疗）作出反应，以促进侵袭性、抗治疗疾病的发展。这里，