The multisystem inflammatory syndrome in children (MIS-C) is a post-viral immunological or hyper-inflammatory complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection commonly seen in older children, who commonly present with fever, multi-systemic involvement including myocardial dysfunction and shock, and hyper-inflammation. The treatment of MIS-C is adapted from the treatment of other immunological or hyper-inflammatory conditions and these treatment protocols are not uniform across the globe, and more so, in India. We propose a uniform management protocol for MIS-C based on our experience of treating MIS-C cases, available evidence till now, and recent guidelines. The aims are to identify children with MIS-C with high sensitivity, recognize other infections or inflammatory processes, stratify treatment based on severity, and manage hyper-inflammatory syndrome.

中文翻译：

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儿童多系统炎症综合征的更新管理方案 (MIS-C)

儿童多系统炎症综合征 (MIS-C) 是严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的病毒后免疫或高炎症并发症，常见于年龄较大的儿童，通常表现为发烧、多系统受累，包括心肌功能障碍和休克，以及过度炎症。MIS-C 的治疗改编自其他免疫或高炎症性疾病的治疗，这些治疗方案在全球范围内并不统一，在印度更是如此。根据我们治疗 MIS-C 病例的经验、迄今为止的可用证据和最近的指南，我们提出了一个统一的 MIS-C 管理方案。目的是识别具有高敏感性的 MIS-C 儿童，识别其他感染或炎症过程，