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Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi-ethnic paediatric atopic dermatitis cohort
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2021-08-19 , DOI: 10.1111/cea.14001 Minke M F van Mierlo 1 , Peter J Caspers 2, 3 , Marieke S Jansen 1 , Gerwin J Puppels 2, 3 , Anouk E M Nouwen 1 , Madelon B Bronner 1 , Luba M Pardo 1 , Michel van Geel 4, 5 , Suzanne G M A Pasmans 1
中文翻译：
天然保湿因子作为多民族小儿特应性皮炎队列中丝聚蛋白突变状态的生物标志物
更新日期：2021-10-27
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2021-08-19 , DOI: 10.1111/cea.14001 Minke M F van Mierlo 1 , Peter J Caspers 2, 3 , Marieke S Jansen 1 , Gerwin J Puppels 2, 3 , Anouk E M Nouwen 1 , Madelon B Bronner 1 , Luba M Pardo 1 , Michel van Geel 4, 5 , Suzanne G M A Pasmans 1
Affiliation
Key message
- Raman spectroscopy is a rapid and non-invasive technique to measure natural moisturizing factor content in AD
- Natural moisturizing factor can predict FLG genotype with a sensitivity of 97% and specificity of 87%
- The thenar eminence's nonlesional skin is a suitable location to predict FLG genotype
中文翻译：
天然保湿因子作为多民族小儿特应性皮炎队列中丝聚蛋白突变状态的生物标志物
关键信息
- 拉曼光谱是一种快速、非侵入性的测量 AD 中天然保湿因子含量的技术
- 天然保湿因子可以预测FLG基因型，敏感性为97%，特异性为87%
- 鱼际隆起的无损伤皮肤是预测FLG基因型的合适位置
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