An ultrathin micro-patterned MXene/PEDOT:PSS-based organic electrochemical transistor biosensor was constructed, which can significantly amplify the amperometric signal and transistor’s performance. A novel interdigitated OECTs biosensor has been developed for reliable determination of survivin for the following considerations: (1) The synergistic effect of intercalated MXene and ionic PEDOT:PSS enhanced the mobility and volumetric capacitance of OECTs biosensor. (2) Compared with the best previous literatures, our assay demonstrated enhanced detection limit of survivin down to 10 pg mL⁻¹, as well as satisfactory selectivity, reproducibility, and reliability. (3) Comparison of OECTs against commercial ELISA kit yielded favorable linearity (Y = 1.0015*X + 0.0039) and correlation coefficient (R² = 0.9717). Those advantages are expected to pave the way to design of an OECTs biosensor with robustness, non-invasiveness, and miniaturization for the point-of-care applications.

Graphical abstract

中文翻译：

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超薄微图案 MXene 和 PEDOT 的组合：聚（苯乙烯磺酸盐）使有机电化学晶体管能够用于安培法测定儿童骨肉瘤中的存活蛋白

构建了一种超薄微图案 MXene/PEDOT:PSS 有机电化学晶体管生物传感器，可显着放大电流信号和晶体管性能。出于以下考虑，已经开发了一种新型交叉指型 OECTs 生物传感器，用于可靠测定存活蛋白：（1）嵌入的 MXene 和离子 PEDOT:PSS 的协同作用增强了 OECTs 生物传感器的迁移率和体积电容。(2) 与之前最好的文献相比，我们的测定证明了存活蛋白的检测限提高到 10 pg mL ^-1，以及令人满意的选择性、重现性和可靠性。(3) OECT 与商业 ELISA 试剂盒的比较产生了良好的线性 ( Y = 1.0015* X+ 0.0039) 和相关系数 ( R ² = 0.9717)。这些优势有望为设计具有鲁棒性、非侵入性和小型化的 OECT 生物传感器用于即时护理应用铺平道路。

图形概要