Sulfated biomolecules are known to influence numerous biological processes in all living organisms. Particularly, they contribute to prevent and inhibit the hypercoagulation condition. The failure of polymeric implants and blood contacting devices is often related to hypercoagulation and microbialcontamination. Here, bioactive sulfated biomacromolecules are mimicked by sulfation of poly(glycerol glycidyl ether) (polyGGE) films. Autoclaving, gamma-ray irradiation and ethylene oxide (EtO) gas sterilization techniques were applied to functionalized materials. The sulfate group density and hydrophilicity of sulfated polymers were decreased while chain mobility and thermal degradation were enhanced post autoclaving when compared to those after EtO sterilization. These results suggest that a quality control after sterilization is mandatory to ensure the amount and functionality of functionalized groups are retained.

中文翻译：

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灭菌条件对硫酸盐官能化 polyGGE 的影响

已知硫酸化生物分子会影响所有生物体中的许多生物过程。特别是，它们有助于预防和抑制高凝状态。聚合物植入物和血液接触装置的故障通常与高凝状态和微生物污染有关。在这里，生物活性硫酸化生物大分子通过聚（甘油缩水甘油醚）（polyGGE）薄膜的硫酸化来模拟。高压灭菌、伽马射线辐照和环氧乙烷 (EtO) 气体灭菌技术应用于功能化材料。与 EtO 灭菌后相比，高压灭菌后硫酸化聚合物的硫酸基团密度和亲水性降低，而链迁移率和热降解增强。