BACKGROUND:Hormonal fertility treatments are associated with increased coagulation factors inducing procoagulant milieu and possibly thrombotic risk. OBJECTIVE:To assess coagulation by ROTEM and coagulation tests in apparently healthy infertile women before oocyte donation procedure. METHODS:We enrolled 51 women (Assisted Reproductive Technology Centre, Florence). ROTEM and coagulation parameters were assessed before the start of infertility treatment. RESULTS:We divided women in 3 groups according to the number of cardiovascular risk factors: Group A (n = 10), Group B (n = 16), and Group C (n = 25). By considering ROTEM Extem test, a significantly increased of MCF, TPI, and G were observed in groups B (p = 0.005, p = 0.03, and p = 0.007) and C (p = 0.01, p = 0.05, and p = 0.005) in comparison to group A. As regards ROTEM Intem test, the TPI and G values were significantly higher in groups B and C in comparison to group A (p < 0.01). MCF by Fibtem test significantly increased in groups B and C than in group A (p = 0.004 and p = 0.002, respectively). FVIII, vWF:Ag and D-dimer values significantly increase according to the presence of≥2 risk factors. CONCLUSIONS:Data from coagulative assessment permit to sensitively identify women with potentially procoagulable state, which represents a risk factor of thromboembolic event during hormone treatment.

中文翻译：

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心血管负担对计划捐卵的表面健康女性凝血途径的影响

背景：激素生育治疗与凝血因子增加相关，诱发凝血环境和可能的血栓形成风险。目的：通过 ROTEM 和凝血试验评估明显健康的不孕妇女在捐卵手术前的凝血情况。方法：我们招募了 51 名女性（佛罗伦萨辅助生殖技术中心）。在开始不孕症治疗之前评估 ROTEM 和凝血参数。结果：我们根据心血管危险因素的数量将女性分为 3 组：A 组（n = 10）、B 组（n = 16）和 C 组（n = 25）。通过考虑 ROTEM Extem 测试，在 B 组（p = 0.005、p = 0.03 和 p = 0.007）和 C（p = 0.01、p = 0.05 和 p = 0.005）中观察到 MCF、TPI 和 G 显着增加) 与 A 组相比。关于 ROTEM Intem 测试，与 A 组相比，B 组和 C 组的 TPI 和 G 值显着更高（p < 0.01）。通过Fibtem 测试的MCF 在B 组和C 组中比在A 组中显着增加（分别为p = 0.004 和p = 0.002）。FVIII、vWF:Ag 和 D-二聚体值根据≥2 个危险因素的存在而显着增加。结论：来自凝血评估的数据允许敏感地识别具有潜在促凝状态的女性，这是激素治疗期间血栓栓塞事件的危险因素。