当前位置：
X-MOL 学术
›
Bioconjugate Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Supramolecular “Click Chemistry” for Targeting in the Body
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-08-20 , DOI: 10.1021/acs.bioconjchem.1c00326 Christopher J Addonizio 1 , Brant D Gates 1 , Matthew J Webber 1
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-08-20 , DOI: 10.1021/acs.bioconjchem.1c00326 Christopher J Addonizio 1 , Brant D Gates 1 , Matthew J Webber 1
Affiliation
|
The fields of precision imaging and drug delivery have revealed a number of tools to improve target specificity and increase efficacy in diagnosing and treating disease. Biological molecules, such as antibodies, continue to be the primary means of assuring active targeting of various payloads. However, molecular-scale recognition motifs have emerged in recent decades to achieve specificity through the design of interacting chemical motifs. In this regard, an assortment of bioorthogonal covalent conjugations offer possibilities for in situ complexation under physiological conditions. Herein, a related concept is discussed that leverages interactions from noncovalent or supramolecular motifs to facilitate in situ recognition and complex formation in the body. Classic supramolecular motifs based on host–guest complexation offer one such means of facilitating recognition. In addition, synthetic bioinspired motifs based on oligonucleotide hybridization and coiled-coil peptide bundles afford other routes to form complexes in situ. The architectures to include recognition of these various motifs for targeting enable both monovalent and multivalent presentation, seeking high affinity or engineered avidity to facilitate conjugation even under dilute conditions of the body. Accordingly, supramolecular “click chemistry” offers a complementary tool in the growing arsenal targeting improved healthcare efficacy.
中文翻译：
用于体内靶向的超分子“点击化学”
精密成像和药物输送领域已经揭示了许多提高靶标特异性并提高疾病诊断和治疗功效的工具。抗体等生物分子仍然是确保主动靶向各种有效载荷的主要手段。然而，近几十年来出现了分子尺度的识别基序，通过设计相互作用的化学基序来实现特异性。在这方面，各种生物正交共价缀合提供了在生理条件下原位络合的可能性。在此，讨论了一个相关概念，该概念利用非共价或超分子基序的相互作用来促进体内的原位识别和复合物形成。基于主客体络合的经典超分子基序提供了一种促进识别的方法。此外，基于寡核苷酸杂交和卷曲螺旋肽束的合成仿生基序提供了原位形成复合物的其他途径。包括对这些不同基序的识别以进行靶向的架构能够实现单价和多价呈现，寻求高亲和力或工程亲合力以促进缀合，即使在身体的稀释条件下也是如此。因此，超分子“点击化学”为不断增长的旨在提高医疗保健功效的武器库提供了补充工具。
更新日期：2021-09-15
中文翻译：
用于体内靶向的超分子“点击化学”
精密成像和药物输送领域已经揭示了许多提高靶标特异性并提高疾病诊断和治疗功效的工具。抗体等生物分子仍然是确保主动靶向各种有效载荷的主要手段。然而，近几十年来出现了分子尺度的识别基序，通过设计相互作用的化学基序来实现特异性。在这方面，各种生物正交共价缀合提供了在生理条件下原位络合的可能性。在此，讨论了一个相关概念，该概念利用非共价或超分子基序的相互作用来促进体内的原位识别和复合物形成。基于主客体络合的经典超分子基序提供了一种促进识别的方法。此外，基于寡核苷酸杂交和卷曲螺旋肽束的合成仿生基序提供了原位形成复合物的其他途径。包括对这些不同基序的识别以进行靶向的架构能够实现单价和多价呈现，寻求高亲和力或工程亲合力以促进缀合，即使在身体的稀释条件下也是如此。因此，超分子“点击化学”为不断增长的旨在提高医疗保健功效的武器库提供了补充工具。
京公网安备 11010802027423号